Selektive Inhibitoren der Dihydrofolat-Reduktase (Nobel-Vortrag) = Selective Inhibitors of dihydrofolate reductase (Nobel lecture)HITCHINGS, G. H.Angewandte Chemie. 1989, Vol 101, Num 7, pp 903-909, issn 0044-8249, 7 p.Article

Expression of dihydrofolate reductase, and of the adjacent EIb region, in an Ad5-dihydrofolate reductase recombinant virusBERKNER, K. L; SHARP, P. A.Nucleic acids research. 1984, Vol 12, Num 4, pp 1925-1941, issn 0305-1048Article

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase―thymidylate synthase gene of Plasmodium falciparumCOWMAN, A. F; MORRY, M. J; BIGGS, B. A et al.Proceedings of the National Academy of Sciences of the United States of America. 1988, Vol 85, Num 23, pp 9109-9113, issn 0027-8424Article

Development and evaluation of an enzyme inhibition assay for methotrexateKELLY, M. G.Annals of clinical biochemistry. 1988, Vol 25, Num 5, pp 516-521, issn 0004-5632Article

A coupled radiometric assay for dihydrofolate reductase based on the oxidative decarboxylation of D-6-phospho-[1-¹⁴C]gluconateRATHOD, P. K; REYES, P.Analytical biochemistry. 1983, Vol 133, Num 2, pp 425-429, issn 0003-2697Article

Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitorTHEN, R. L; KELLER, M.Zentralblatt für Veterinärmedizin. Reihe B. Infectious diseases, immunology, food hygiene, veterinary public health. 1988, Vol 35, Num 2, pp 114-120Article

Evidence that a point mutation in dihydrofolate reductase―thymidylate synthase confers resistance to pyrimethamine in falciparum malariaPETERSON, D. S; WALLIKER, D; WELLEMS, T. E et al.Proceedings of the National Academy of Sciences of the United States of America. 1988, Vol 85, Num 23, pp 9114-9118, issn 0027-8424Article

Design of a new substituted 2,4-diamino-5-benzylpyrimidine as inhibitor of bacterial dihydrofolate reductase assisted by molecular graphicsCZAPLINSKY, K.-H; KANSY, M; SEYDEL, J. K et al.Quantitative structure-activity relationships. 1987, Vol 6, Num 2, pp 70-72, issn 0931-8771Article

A flow microcalorimetric method for enzyme activity measurements: application to dihydrofolate reductaseSICA, L; GILLI, R; BRIAND, C et al.Analytical biochemistry. 1987, Vol 165, Num 2, pp 341-348, issn 0003-2697Article

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analoguesKUYPER, L. F; ROTH, B; GOODFORD, P. J et al.Journal of medicinal chemistry (Print). 1985, Vol 28, Num 3, pp 303-311, issn 0022-2623Article

The ¹H-NMR assignments of the aromatic resonances in complexes of Lactobacillus casei dihydrofolate reductase and the origins of their chemical shiftsBIRDSALL, B; ARNOLD, J. R. P; JIMENEZ-BARBERO, J et al.European journal of biochemistry (Print). 1990, Vol 191, Num 3, pp 659-668, issn 0014-2956, 10 p.Article

A novel form of human polymorphism involving the hDHFR-ψ₁ pseudogene identifies three RFLPsANAGNOU, N. P; ANTONARAKIS, S. E; O'BRIEN, S. J et al.Nucleic acids research. 1987, Vol 15, Num 13, issn 0305-1048, 5501Article

Thymidylate synthase-dihydrofolate reductase in protozoaIVANETICH, K. M; SANTI, D. V.Experimental parasitology. 1990, Vol 70, Num 3, pp 367-371, issn 0014-4894Article

The thymidylate synthesis cycle and anticancer drugsDOUGLAS, K. T.Medicinal research reviews (Print). 1987, Vol 7, Num 4, pp 441-475, issn 0198-6325Article

Evidence for kinetic and immunologic heterogeneity of dihydrofolate reductase in L1210 leukemia cellsPERWAIZ IQBAL, M; ROTHENBERG, S. P; DA COSTA, M et al.Biochemical medicine and metabolic biology. 1991, Vol 46, Num 2, pp 196-207, issn 0885-4505Article

Trimethoprim binds in a bacterial mode to the wild-type and E30D mutant of mouse dihydrofolate reductaseGROOM, C. R; THILLET, J; The Journal of biological chemistry (Print). 1991, Vol 266, Num 30, pp 19890-19893, issn 0021-9258Article

Adriamycin, a drug interacting with acidic phospholipids, blocks import of precursor proteins by isolated yeast mitochondriaEILERS, M; ENDO, T; SCHATZ, G et al.The Journal of biological chemistry (Print). 1989, Vol 264, Num 5, pp 2945-2950, issn 0021-9258Article

Anchorage of the Chinese hamster dihydrofolate reductase gene to the nuclear scaffold occurs in an intragenic regionKAS, E; CHASIN, L. A.Journal of molecular biology. 1987, Vol 198, Num 4, pp 677-692, issn 0022-2836Article

Two RFLPs for the human dihydrofolate reductase gene (DHFR)FEDER, J. N; BOWCOCK, A; CAVALLI-SFORZA, L. L et al.Nucleic acids research. 1987, Vol 15, Num 14, issn 0305-1048, 5906Article

Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitroCHU, E; TAKIMOTO, C. H; VOELLER, D et al.Biochemistry (Easton). 1993, Vol 32, Num 18, pp 4756-4760, issn 0006-2960Article

Hydrogen bonding effects on ³¹P NMR shielding in the pyrophosphate group of NADPH bound to L. casei dihydrofolate reductaseGEROTHANASSIS, I. P; BIRDSALL, B; FEENEY, J et al.FEBS letters. 1991, Vol 291, Num 1, pp 21-23, issn 0014-5793Article

A gene for dihydrofolate reductase in a herpesvirusTRIMBLE, J. J; MURTHY, S. C. S; BAKKER, A et al.Science (Washington, D.C.). 1988, Vol 239, Num 4844, pp 1145-1147, issn 0036-8075Article

Direct experimental evidence for competitive inhibition of dihydrofolate reductase by methotrexateWALTHAM, M. C; HOLLAND, J. W; ROBINSON, S. C et al.Biochemical pharmacology. 1988, Vol 37, Num 3, pp 535-539, issn 0006-2952Article

Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductaseTAIRA, K; BENKOVIC, S. J.Journal of medicinal chemistry (Print). 1988, Vol 31, Num 1, pp 129-137, issn 0022-2623Article

Classification of plasmid-encoded dihydrofolate reductases conferring trimethoprim resistanceAMYES, S. G. B; TOWNER, K. J; YOUNG, H.-K et al.Journal of medical microbiology. 1992, Vol 36, Num 1, pp 1-3, issn 0022-2615Article